KMID : 0869220160200020075
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Journal of Korean Geriatric Psychiatry 2016 Volume.20 No. 2 p.75 ~ p.79
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A Voxel Wise Analysis of Cerebral Beta Amyloid Retention in Healthy Controls and Subjects with Amnestic Mild Cognitive Impairment and Alzheimer¡¯s Disease
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Cho Yea-Ni
Um Yoo-Hyun Kim Tae-Won Seo Ho-Jun Jeong Jong-Hyun Hong Seung-Chul Han Jin-Hee Baek In-Ho Lim Hyun-Kook
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Abstract
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Objective£ºThe purpose of the study was to compare cortical amyloid deposition using 18F-florbetaben and positron emission tomography (PET) in healthy controls and subjects with amnestic mild cognitive impairment (aMCI) and Alzheimer¡¯s disease (AD).
Methods£ºWe investigated 25 patients : 10 age-matched healthy controls, 10 patients with aMCI and 5 with AD. All participants underwent PET after intravenous injection of 300 MBq of 18F-florbetaben. The 90 min post-injection brain PET data were analysed using statistical parametric mapping.
Results£ºWhen compared to healthy controls, amyloid deposition was significantly higher in frontal lobe medial frontal gyrus, limbic lobe posterior cingulate, parietal lobe precuneus, sub-loba insula, temporal lobe superior temporal gyrus, parietal lobe inferior parietal lobule, temporal lobe middle temporal gyrus, parietal lobe supramarginal gyrus, occipital lobe middle temporal gyrus of patient group (family wise error correction p<0.05).
Conclusion£ºThese results indicate 18F-florbetaben to be an efficacious ¥â-amyloid-targeted tracer. Subjects with aMCI, AD could be easily differentiated from healthy controls by assessment of the PET data.
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KEYWORD
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¥â-amyloid, Positron emission tomography, 18F-florbetaben, Alzheimer¡¯s disease
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